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Perianal Fistulas #1588
02/13/10 06:26 AM
02/13/10 06:26 AM
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Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Northern CA

Last edited by MaxaLisa; 04/24/14 10:18 PM.
Re: Perianal Fistulas/Genetics [Re: MaxaLisa] #14514
03/05/10 05:27 AM
03/05/10 05:27 AM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Posts: 19,670
Northern CA
The genetics of Perianal Fistulas/Anal Furuniculosis
http://www.ncbi.nlm.nih.gov/pubmed/17999655
--- http://www.koirangeenit.fi/dmdocuments/perianaalifistelia.pdf (pdf version of above)
http://www.ingentaconnect.com/content/mksg/tan/2009/00000073/00000003/art00005
http://www.rvc.ac.uk/Staff/bcatchpole.cfm


DNA Test for PF (cheek swab, testing done in Finland)
http://www.genoscoper.com/in_english2/gene_tests/gene_tests/anal_furunculosis-dla_risk_gen/
This test is now recognized by the OFA for a $15 charge (3/2011)

(GSDs that do not carry this gene can still develop perianal fistulas due to other causes, either genetic or environmental, but they develop them at a much lower frequency.)

Quote:
Anal furunculosis - DLA risk gene (from the link just above):

Heriditary form of anal furunculosis exists among German Shepherds and the disease is usually found in middle aged or older dog. The symptoms of the disease are severe. Inflammations around the anal area and rectum are typical and often the inflamed areas are surgically removed. The disease is treated with antibiotics, syclosporine and corticosteroids.

The cause of anal furunculosis is unknown but recent studies have revealed that it has a hereditary immunological backround. It is an autoimmune disease, which can be activated by different bacterial or yeast inflammations and stress. The disease is very difficult for the dog and usually hard to treat. Over 80% of treated anal furunculosis occur among German Shepherds. This clearly indicates familial susceptibility among the breed.

Recent studies have revealed that susceptibility to anal furunculosis is associated with DRB*00101 allele. This form of immunegene was found mainly in dogs that suffer from anal furunculosis. The risk of getting anal furunculosis is 5 times higher if the dog carries DRB*00101 allele. DRB*00101 homozygote catch the disease at younger age than heterozygote. Anal furunculosis is not monogenic recessive disease and it is likely that other unknown genes are involved. This means that even if a dog carries the risk allele it will not necessarily get the disease because there might be some other genetic or environmental factors that prevent the dog from having the disease. In addition some dogs that do not carry the risk allele have anal furunculosis so this also proves that there are several genetic factors behind the disease.

However the DRB*00101 allele increases the risk of getting anal furunculosis and its frequency in the population should be lowered. Dogs that carry the risk allele need careful consideration before using them for breeding purposes.

The results of the test are reported as follows:

NORMAL: Do not carry the risk allele DRB*00101 and has therefore no increased risk of developing anal furunculosis.

CARRIER: (Heterozygote): Carries one copy of the DRB*00101 allele and because of the dominant inheritance has therefore a risk 5 times higher of developing anal furunculosis. Carrier can also transfer the defect to approximately 50% of its offsprings.

AFFECTED: (Homozygote): Carries two copies of the DRB*00101 allele and has therefore a risk 5 times higher of developing perianal fistelia than a normal dog. Sick homozygote usually develops the disease at younger age than a heterozygote. It will also transfer the gene defect to all of its offsprings.

---------------------------------

Reference:

Lorna J Kennedy, Turlough O’Neill, Arthur House, Annette Barnes, Kaisa Kyöstilä, John Innes, Neale Fretwell, Michael J Day, Brian Catchpole, Hannes Lohi and William E R. Ollier Risk of Anal Furunculosis in German Shepherd dogs is associated with the Major Histocompatibility Complex, Tissue Antigens, 71(1):51-6, 2008.

Last edited by MaxaLisa; 03/12/11 11:29 PM.
Re: Perianal Fistulas/Threads [Re: MaxaLisa] #97182
10/23/10 07:03 AM
10/23/10 07:03 AM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Joined: Jan 2010
Posts: 19,670
Northern CA

Last edited by MaxaLisa; 02/16/14 10:18 PM.
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