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Re: New drug for osteoarthritis [Re: Kris] #343872
04/01/17 01:08 AM
04/01/17 01:08 AM
Joined: Jan 2010
Posts: 19,513
Northern CA
MaxaLisa Offline

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MaxaLisa  Offline

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Originally Posted By: Kris
...And a list of the drugs that are a problem for an MDR1 dog: https://vcpl.vetmed.wsu.edu/problem-drugs


Just a side note - there are a lot of human mdr1 drugs which may or may not affect canines. Some of them have been tested, many not. With indy, I would always check to see if they affected humans if they weren,t on that list, and then went slow, or I emailed the lab. Indy was only a 1/2 mutant. People can have this too (I do wink )


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: New drug for osteoarthritis [Re: Kris] #343873
04/01/17 01:11 AM
04/01/17 01:11 AM
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Northern CA
MaxaLisa Offline

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Northern CA
Originally Posted By: Kris
Lisa, thank you for posting about the MDR1 gene and this drug. I was all excited about this, but now we would have to proceed carefully since Sammy does have the gene. Thankfully, right now he's just taking Glycoflex 3 supplements and doesn't need anything stronger.

I specifically emailed Dr. Mealey. She recommended against it for mdr1 dogs frown I wonder if a dose modification would work, like a chihuahua size dose lol.

Does Sammie have any neurological deficits?


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
Re: New drug for osteoarthritis [Re: MaxaLisa] #343874
04/01/17 01:47 AM
04/01/17 01:47 AM
Joined: Feb 2010
Posts: 2,174
Colorado
Kris Offline
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Kris  Offline
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Originally Posted By: MaxaLisa


Does Sammie have any neurological deficits?


Well, not from the MDR1 gene! rofl Seriously though, once he got past the recovery after that ivermectin shot, I've never seen any lingering effects. I'm really disappointed that Dr. Mealey advises against using it. I was going to email too - thanks for getting that answer! He doesn't need it yet, but was looking forward when/if he does and thought this was a great solution. Back to the drawing board...


Kris
~~~~~~~~~~~~~~~~~~~~~~~~
Samson, GSD, 10/13/07
Annabel, Keeshond, 4/21/11
Petie, Toy Poodle, 5/5/07
Kitties: Meezer, Bob, Mia and Dewey
Re: New drug for osteoarthritis [Re: Kris] #343875
04/01/17 02:46 AM
04/01/17 02:46 AM
Joined: Jan 2010
Posts: 19,513
Northern CA
MaxaLisa Offline

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MaxaLisa  Offline

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Northern CA
Glad to hear about the full recovery!

Maybe by the time Sammie needs it, they will have tested it on canines. I guess they need the raw drug for testing and haven't been able to obtain it.


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
Re: New drug for osteoarthritis [Re: MaxaLisa] #343877
04/01/17 03:45 AM
04/01/17 03:45 AM
Joined: Feb 2010
Posts: 2,174
Colorado
Kris Offline
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Kris  Offline
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I figured since it was so new, they probably hadn't tested it yet. Thanks for info. Lisa!


Kris
~~~~~~~~~~~~~~~~~~~~~~~~
Samson, GSD, 10/13/07
Annabel, Keeshond, 4/21/11
Petie, Toy Poodle, 5/5/07
Kitties: Meezer, Bob, Mia and Dewey
Re: New drug for osteoarthritis [Re: Kris] #343883
04/01/17 11:10 PM
04/01/17 11:10 PM
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Shilohsmom Offline OP
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I went down and had a nice long conversation with our Vet, the one I thought was still on vacation, and I'm feeling much better. At this point and with all the work that's been done with my pups I feel comfortable giving them this new drug. I did let her know what the other vet said about purebred GSDs not being affected by the MDR1 gene, so hopefully she is corrected on that in the future.

Gonna have more questions but will start a new thread.


Rosa

Proud Mom to Eli and Kodiak
and never to be forgotten, Shiloh and Shoshi
Every dog deserves to have a human that thinks its the greatest dog that ever lived!
Re: New drug for osteoarthritis [Re: Shilohsmom] #343892
04/02/17 02:27 AM
04/02/17 02:27 AM
Joined: Jan 2010
Posts: 19,513
Northern CA
MaxaLisa Offline

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MaxaLisa  Offline

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Northern CA
So you have about a 90% chance your dog won't be affected. Typically, unless you specifically ask, this will not be tested for, it is not run at a regular lab.

Good luck, hope it goes well!


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
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