Re: mdr1 genetic mutation
[Re: MaxaLisa]
#103512
11/12/10 04:13 PM
11/12/10 04:13 PM
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Joined: Nov 2010
Posts: 75
Frenz
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Member
Joined: Nov 2010
Posts: 75
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I had the MDR1 gene tested at WSU for my dog. WSU was quick to ship the kit, taking the sample was easy, and I got results in 2 weeks. Well worth the money IMO.
Shelley
Shelley
Frenzi, CGC
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Re: mdr1 genetic mutation
[Re: Frenz]
#103774
11/13/10 02:48 PM
11/13/10 02:48 PM
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Joined: May 2010
Posts: 123
HeidiGSD
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Joined: May 2010
Posts: 123
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I had the MDR1 gene tested at WSU for my dog. WSU was quick to ship the kit, taking the sample was easy, and I got results in 2 weeks. Well worth the money IMO. I agree...I just had Nikki tested last month 
Michaela
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Olivia von Jagenstadt "Nikki" - 11/21/2009 Heidi von Shiloh - 2/10/1995 - 2/21/2009
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Re: mdr1 genetic mutation
[Re: HeidiGSD]
#110585
12/02/10 04:39 PM
12/02/10 04:39 PM
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Joined: Feb 2010
Posts: 2,032 MA
shepnterrier
Pooh-Bah
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Pooh-Bah
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Posts: 2,032
MA
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I just baffles me each time a see a Heartgard package for medium sized dogs with the picture of a border collie on it.
Sarah Chip vom Dog Pound, border terrior, Director of Rodent Control, CGC Elly von Rescue, GSD, CGC, HI(C) Captain Jack, Mama Blue, Little Orca, Bübchen, Tux, Cherub (pocket lions)
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Re: mdr1 genetic mutation
[Re: MaxaLisa]
#110670
12/02/10 07:51 PM
12/02/10 07:51 PM
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Joined: Feb 2010
Posts: 2,199 Colorado
Kris
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Posts: 2,199
Colorado
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I give Sammy Heartguard but not before I confirmed that it was okay with Dr. Mealey at WSU. Haven't had any problems at all because the dosage is so small (and he tested mutant/mutant so would be pretty susceptible to a reaction).
I was nervous, but she assured me that they had no concern whatsoever with the monthly HW preventatives. I don't know that it would matter (because if they were going to react, I think it would be with the first dose they took), but we only give HW preventative six months out of the year here in Colorado - May through October.
Last edited by MaxaLisa; 02/12/11 04:29 AM. Reason: combined posts
Kris ~~~~~~~~~~~~~~~~~~~~~~~~ Samson, GSD, 10/13/07 Annabel, Keeshond, 4/21/11 Petie, Toy Poodle, 5/5/07 Kitties: Meezer, Bob, Mia and Dewey
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Re: mdr1 genetic mutation
[Re: Kris]
#133154
02/12/11 05:19 AM
02/12/11 05:19 AM
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Joined: Jan 2011
Posts: 149
unloader
Member
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Member
Joined: Jan 2011
Posts: 149
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As requested : MDR1 and Relatively adrenal insufficiency I thought some of you that have Mutant/Mutant dogs might find this helpful. I received an email via my vet from WSU stating that dogs with the MDR1 mutation can have relative adrenal insufficiency (lower basal cortisols and lower basal ACTH concentrations than dogs that do not have the MDR1 mutation) They haven't tested Mutant/Normal dogs, but they could suffer from the same issue as Mutant/Mutant dogs. http://onlinelibrary.wiley.com/doi/10.1111/j.1476-4431.2006.00196.x/abstractThe WSU vet indicated that doing a ACTH stim test might be useful. The WSU vet also said "Research mice that have had the MDR1 gene genetically “knocked out” have a higher incidence of inflammatory bowel disease than “normal” mice."
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