Monthly repeated oral administration of spinosad and milbemycin oxime over six months revealed
evidence of spinosad and milbemycin oxime accumulation in juvenile dogs. Accumulation cannot be
discounted in adult dogs. In juvenile dogs, repeated oral administration of spinosad and milbemycin
oxime over six months resulted in the trough plasma concentrations of spinosad and milbemycin
increasing throughout the study. Trough concentrations of spinosad doubled monthly up to month 5.
The increase in plasma concentrations was strongly correlated with an increase in terminal elimination
half-lives.

In adult dogs, after repeated oral administration of spinosad and milbemycin oxime for six consecutive
months, increases in elimination half-lives were observed up to month 3[Trough concentrations of spinosad doubled monthly up to month 5]. In a separate study with three
consecutive monthly administrations, no increases in Cmax, AUC, or elimination half-lives were noted
when comparing values from the third and first months. Sufficient data on the Cmax or AUC following
repeated oral administration are not available beyond three months of treatment.


http://www.ema.europa.eu/docs/en_GB/docu...WC500152457.pdf

Thomas Longfellow DVM said:
March 18, 2014 at 10:25 pm
I am also a veternarian and I have no problem stating that this product can and has harmed dogs. I have seen it first hand, I have treated it first hand. I have reported it to Elanco and the FDA. I have pulled it from my shelves. There are other heartworm products and heartworm preventative is needed. Use an alternative but not Trifexis.

Jan Harris said:
March 17, 2014 at 3:47 pm
Since Elanco did not have a contact email address, I had to call them and leave a message. The call was returned promptly. I first asked the receptionist, she pushed me over to a vet tech, who pushed me over to an Elanco vet. This is verbatim:

My Question to Elanco:

I have read the same wording over and over, that vets have found no connection between Trifexis and the necropsied dogs. My question is – exactly what WOULD a necropsy show for a dog who died of insecticidal poisoning? Specifically Trifexis?

Her Answer:

“There isn’t much that you can actually find from a systemic medication.” “What we look for are underlying causes, pre-existing conditions – any other indication that the dog had any other reason for dying.” “There is nothing really definitive to look for” “There is no established link” “We look for what else was going on with the dog.” “For instance, if the dog had a tumor, etc. then that is why we assume the dog died of it.”

My Question:

But even finding another problem with the dog, that’s not exclusive of the dog actually dying from Trifexis, is it?

Her Answer:

“No, you’re right. But all we can do is look for things that can explain the dog’s death.” “There is nothing pathognomonic to look for.” (pathognomonic = a term, often used in medicine, that means characteristic for a particular disease.)

My Question:

Why are there different safety regulations on the use of Trifexis in Europe than in the US? In Europe people are cautioned never to use Trifexis on dogs under 8.5 lbs, and never use it for more than 6 consecutive months in a year.

Her Answer:

“The Trifexis used in Europe is the very same as the Trifexis used here in the US. But the regulatory bodies are specific to each individual countries. They do their own safety experiments and we do ours.”

Elanco admits are NOT looking for Trifexis poisoning – they are ONLY looking for OTHER explanations of the dogs’ illnesses and deaths. I encourage folks to call Elanco themselves: 1-877-352-6261

....

Jan Harris said:
March 18, 2014 at 8:49 am
And, by the way, the 4 littermates which Elanco said died of “myocarditis” is NOT proof that they did not die of Trifexis poisoniing. Myocarditis simply means “inflammation of the heart” – which can be caused by any number of things INCLUDING drug reaction.

Some insecticides will gather in liver and fat (providing the poison was given over a long period of time) but MANY insecticides are NOT apparent at all from a necropsy (only showing nonspecific internal bleeding and organ enlargement/changes) – and many times the determination of poisoning death is by SYMPTOMS and knowledge of previous ingestion of the dog.

I contacted various vet sites which defended the use of Trifexis and asked THEM pointblank of exactly what a necropsy would show of a dog who died of insecticidal poisoning….guess what – they had NO answer…..and said I should contact Elanco (which I did). I even emailed the question to the AVMA – but they never responded at all. I hope folks will call Elanco themselves and ask: “What exactly WOULD a necropsy show if the dog died of Trifexis poisoning?”

Hello:

I am Lisa Fox (Phoenixfoxx), the attorney who is investigating the possibility of a class-action lawsuit against Elanco/Lilly re: Trifexis. I am a plaintiff's attorney who had no desire whatsover to sue a multi-billion-dollar drug company until last Thursday morning, when my beautiful, healthy best friend was poisoned to death by Trifexis within three days of his first (fatal) dose. Class action suits are big, and expensive (for the lawyers, not the plaintiffs), and I have begun the process of seeking out other attorneys who may be interested in doing this with me. No amount of money will ever replace those of us who, like me and many others, lost our dogs needlessly and painfully just to make vets more money and Lilly's shareholders and top brass even richer. However, class-action suits make companies wake up and pay attention, so this may be a very effective way to get the word out there that TRIFEXIS KILLS DOGS. Please let me know who may be interested. As I posted previously, there IS strength and power in numbers, even against a leviathan like Eli Lilly.

https://www.facebook.com/freakles2/posts/933015516714785
Her FB page: https://www.facebook.com/phoenix.foxx.5