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Re: Trifexis Adverse Events [Re: Götz] #289529
07/18/13 04:16 PM
07/18/13 04:16 PM
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Posts: 1,746
SE Wisconsin
FurKids Offline
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Oh wow -- I was actually thinking of talking to our vet about this product. New does bother me ... I think I'll stick to what I'm using now.


Deb • Nissa & Gracie
Forever in My Heart • Riley, Hannah, Damien, Katy, Crocket, Kayla, Gypsy, Toby and Cookie
Re: Trifexis Adverse Events [Re: FurKids] #289544
07/18/13 06:03 PM
07/18/13 06:03 PM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline

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New bothers me too!

There are a lot of dogs out there doing fine on this, but there are enough that are getting sick, some dying, that I'm really glad that someone is looking into the scope of the problem.

I've post this on some of the forums I belong to:

...
Please spread the word to those that might have experienced issues with this drug. I have been following the FB group "Trifexis Kills DOGS", where, on a fairly regular basis, dogs are having bad reactions to this med, including some fatal reactions. It is unknown the extent of this problem. However, a lawyer is trying to gather stories, to see if there is cause to take action. Here is the webpage:

http://www.protectingtheconsumer.com/trifexis-flea-medication.php

Thanks,

LisaT
(Permision to cross-post)


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

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Re: Trifexis Adverse Events [Re: MaxaLisa] #289548
07/18/13 06:18 PM
07/18/13 06:18 PM
Joined: Feb 2010
Posts: 11,815
Los Lunas, NM
Kayos Offline

Can't Figure Tech Stuff Out
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Kayos has a hard time tolerating Ivermectin. I never had her tested for MDR1 but I bet she may hvae it. I have always used other stuff on her. She is the only dog on Trifexis right now and has not had a problem with it.

Due to furlough and money, I have gone to liquid Ivermectin for Havoc and Mayhem.

I certainly will be more watchful with this med now but will still use it.


Kathy

PAM, URO3, UCD, UACH Tidmores Rising Star Lydia "Mayhem" CD,BN,RE,AX,AJP,OFP,P1J,CA,DJ,HT,TKN,TC,CGCU, RATN 4/4/12
Jeli, (Pembroke Welsh corgi) CGC, RATI 5/13/19

Lucky, Wolf, Max, Kayos, Havoc - gone not forgotten. gsdhalo
Re: Trifexis Adverse Events [Re: Kayos] #289584
07/18/13 09:23 PM
07/18/13 09:23 PM
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Posts: 19,670
Northern CA
MaxaLisa Offline

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It's always possible that the med is interacting with, say, another tick/flea product, or some genetic susceptibility, who knows shrug It seems like reactions occur in the first several times it has been used, but I haven't read all of the reports.


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
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Re: Trifexis Adverse Events [Re: MaxaLisa] #289695
07/19/13 08:25 PM
07/19/13 08:25 PM
Joined: May 2013
Posts: 205
Northern, CA
Liz S. Offline
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Northern, CA
We just got it for all four of our dogs (Van, our GSD as well as Buddy, our Chihuahua, Mackie our Pomeranian and Pirate our Doxie).... now I am scared to give it to them!!!


Mom to four awesome human kids, and my 5 furry ones:

Van - nearly 3 yrs old.
Daenerys (Dani)GSD, 1 yr
Mackie - Pomeranian, 14 years
Buddy - Chihuahua, 4 years
Pirate -Dachshund, 10 years
Callie - Long Haired Tortie Cat, 6 years
Re: Trifexis Adverse Events [Re: Liz S.] #289713
07/20/13 03:04 AM
07/20/13 03:04 AM
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Northern CA
MaxaLisa Offline

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Tough decisions!


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
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Re: Trifexis Adverse Events [Re: MaxaLisa] #289720
07/20/13 05:10 AM
07/20/13 05:10 AM
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Buffalo
BowWowMeow Offline
Carpal Tunnel
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This is why I don't use pesticides on my dogs. Very sad, for the people who trusted their vets and the drug companies. Not to mention bee colony collapse, the decline of songbirds and now this bat fungus (yes, I'm convinced that pesticides are no good). mad


Ruth

Rafi, the german malaroo, age 9.5ish
http://www.dogster.com/dogs/693238

Varda & Gio (the crazy cattens)
...............
Warming my heart:
Queen Cleopatra
Chama
Kai
Basu
Massie
Re: Trifexis Adverse Events [Re: BowWowMeow] #299449
11/12/13 05:20 AM
11/12/13 05:20 AM
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Northern CA
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My phone doesn't have Flash, so I can't see the video, but here is a news report:

http://m.wsbtv.com/news/news/local/dog-owners-question-link-between-meds-and-deaths/nbpSg/


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #299755
11/16/13 08:37 PM
11/16/13 08:37 PM
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Northern CA
MaxaLisa Offline

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People avoiding Trifexis should also avoid ComboGuard ( Combo Guard ):
http://www.vethical.com/comboguard.html


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #300865
11/29/13 04:51 PM
11/29/13 04:51 PM
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Northern CA
MaxaLisa Offline

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MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #309669
02/28/14 03:14 AM
02/28/14 03:14 AM
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MaxaLisa Offline

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I saw in a document from the European Union, that they don't recommend using Trifexis for more than 6 months in a row.

I did find this, which says that over time, it does accumulate and does not eliminate from the body on a consistent basis over the initial many months.

Quote:
Monthly repeated oral administration of spinosad and milbemycin oxime over six months revealed
evidence of spinosad and milbemycin oxime accumulation in juvenile dogs. Accumulation cannot be
discounted in adult dogs. In juvenile dogs, repeated oral administration of spinosad and milbemycin
oxime over six months resulted in the trough plasma concentrations of spinosad and milbemycin
increasing throughout the study. Trough concentrations of spinosad doubled monthly up to month 5.
The increase in plasma concentrations was strongly correlated with an increase in terminal elimination
half-lives.

In adult dogs, after repeated oral administration of spinosad and milbemycin oxime for six consecutive
months, increases in elimination half-lives were observed up to month 3[Trough concentrations of spinosad doubled monthly up to month 5]. In a separate study with three
consecutive monthly administrations, no increases in Cmax, AUC, or elimination half-lives were noted
when comparing values from the third and first months. Sufficient data on the Cmax or AUC following
repeated oral administration are not available beyond three months of treatment.


http://www.ema.europa.eu/docs/en_GB/docu...WC500152457.pdf


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
Re: Trifexis Adverse Events [Re: MaxaLisa] #310125
03/04/14 09:56 PM
03/04/14 09:56 PM
Joined: Feb 2010
Posts: 11,815
Los Lunas, NM
Kayos Offline

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I have not had any issues with it. But I also do not give it every 30 days nor do I use it year round. Kayos does not tolerate Ivermectic so she is the only one that gets it.


Kathy

PAM, URO3, UCD, UACH Tidmores Rising Star Lydia "Mayhem" CD,BN,RE,AX,AJP,OFP,P1J,CA,DJ,HT,TKN,TC,CGCU, RATN 4/4/12
Jeli, (Pembroke Welsh corgi) CGC, RATI 5/13/19

Lucky, Wolf, Max, Kayos, Havoc - gone not forgotten. gsdhalo
Re: Trifexis Adverse Events [Re: Kayos] #311186
03/19/14 02:48 AM
03/19/14 02:48 AM
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Northern CA
MaxaLisa Offline

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The AVMA has "cleared" Trifexis:
http://atwork.avma.org/2013/11/15/update-on-media-rumors-regarding-trifexis/

Many replies talk about the problems dogs are having with the dog, some replies argue this, but these two caught my eye....

Quote:
Thomas Longfellow DVM said:
March 18, 2014 at 10:25 pm
I am also a veternarian and I have no problem stating that this product can and has harmed dogs. I have seen it first hand, I have treated it first hand. I have reported it to Elanco and the FDA. I have pulled it from my shelves. There are other heartworm products and heartworm preventative is needed. Use an alternative but not Trifexis.


Quote:
Jan Harris said:
March 17, 2014 at 3:47 pm
Since Elanco did not have a contact email address, I had to call them and leave a message. The call was returned promptly. I first asked the receptionist, she pushed me over to a vet tech, who pushed me over to an Elanco vet. This is verbatim:

My Question to Elanco:

I have read the same wording over and over, that vets have found no connection between Trifexis and the necropsied dogs. My question is – exactly what WOULD a necropsy show for a dog who died of insecticidal poisoning? Specifically Trifexis?

Her Answer:

“There isn’t much that you can actually find from a systemic medication.” “What we look for are underlying causes, pre-existing conditions – any other indication that the dog had any other reason for dying.” “There is nothing really definitive to look for” “There is no established link” “We look for what else was going on with the dog.” “For instance, if the dog had a tumor, etc. then that is why we assume the dog died of it.”

My Question:

But even finding another problem with the dog, that’s not exclusive of the dog actually dying from Trifexis, is it?

Her Answer:

“No, you’re right. But all we can do is look for things that can explain the dog’s death.” “There is nothing pathognomonic to look for.” (pathognomonic = a term, often used in medicine, that means characteristic for a particular disease.)

My Question:

Why are there different safety regulations on the use of Trifexis in Europe than in the US? In Europe people are cautioned never to use Trifexis on dogs under 8.5 lbs, and never use it for more than 6 consecutive months in a year.

Her Answer:

“The Trifexis used in Europe is the very same as the Trifexis used here in the US. But the regulatory bodies are specific to each individual countries. They do their own safety experiments and we do ours.”

Elanco admits are NOT looking for Trifexis poisoning – they are ONLY looking for OTHER explanations of the dogs’ illnesses and deaths. I encourage folks to call Elanco themselves: 1-877-352-6261

....

Jan Harris said:
March 18, 2014 at 8:49 am
And, by the way, the 4 littermates which Elanco said died of “myocarditis” is NOT proof that they did not die of Trifexis poisoniing. Myocarditis simply means “inflammation of the heart” – which can be caused by any number of things INCLUDING drug reaction.

Some insecticides will gather in liver and fat (providing the poison was given over a long period of time) but MANY insecticides are NOT apparent at all from a necropsy (only showing nonspecific internal bleeding and organ enlargement/changes) – and many times the determination of poisoning death is by SYMPTOMS and knowledge of previous ingestion of the dog.

I contacted various vet sites which defended the use of Trifexis and asked THEM pointblank of exactly what a necropsy would show of a dog who died of insecticidal poisoning….guess what – they had NO answer…..and said I should contact Elanco (which I did). I even emailed the question to the AVMA – but they never responded at all. I hope folks will call Elanco themselves and ask: “What exactly WOULD a necropsy show if the dog died of Trifexis poisoning?”


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #320855
07/31/14 03:20 AM
07/31/14 03:20 AM
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Northern CA
MaxaLisa Offline

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Wouldn't touch this stuff with a 10 foot pole - no way to tell which dogs will react, and if they do okay on it initially, for how long will that last. Tests in the deaths are inconclusive, but the necropsies reported on FB typically show no other cause of death either.

7/30/2014 update on Trifexis deaths:
http://www.wsbtv.com/news/news/owners-vets-reporting-even-more-deaths-connected-t/ngq59/

Last edited by MaxaLisa; 07/31/14 08:21 AM.

MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #320871
07/31/14 12:45 PM
07/31/14 12:45 PM
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Ohio
PositiveDog Offline
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I haven't followed this recently and my dogs have had no (known) adverse reactions to Trifexis.

However, I was unable to shake growing unease from giving a combo drug. For that reason, I discontinued using it after several months.

I am now giving Heartgard and Nexgard and give them a few days apart. I feel better about this. I will discontinue Nexgard when the temps drop.

All these products are scary to me, but I will not leave my dogs unprotected for heartworm. And they will be treated every 30 days and get HW tested annually.


Bonnie

With approval of my friends:

SamCat, 03/2011
Bennie the 12 1/2% GSD 02/2013

Seiko, Solo, Sophie, Skye and Buddy - bridge dogs who taught me so much
Re: Trifexis Adverse Events [Re: PositiveDog] #321059
08/04/14 01:51 AM
08/04/14 01:51 AM
Joined: Feb 2010
Posts: 11,815
Los Lunas, NM
Kayos Offline

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NO issues with it what so ever.......


Kathy

PAM, URO3, UCD, UACH Tidmores Rising Star Lydia "Mayhem" CD,BN,RE,AX,AJP,OFP,P1J,CA,DJ,HT,TKN,TC,CGCU, RATN 4/4/12
Jeli, (Pembroke Welsh corgi) CGC, RATI 5/13/19

Lucky, Wolf, Max, Kayos, Havoc - gone not forgotten. gsdhalo
Re: Trifexis Adverse Events [Re: Kayos] #322694
09/09/14 10:59 PM
09/09/14 10:59 PM
Joined: Jan 2010
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Northern CA
MaxaLisa Offline

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For dogs that have been harmed by Trifexis, please share:

Quote:
Hello:

I am Lisa Fox (Phoenixfoxx), the attorney who is investigating the possibility of a class-action lawsuit against Elanco/Lilly re: Trifexis. I am a plaintiff's attorney who had no desire whatsover to sue a multi-billion-dollar drug company until last Thursday morning, when my beautiful, healthy best friend was poisoned to death by Trifexis within three days of his first (fatal) dose. Class action suits are big, and expensive (for the lawyers, not the plaintiffs), and I have begun the process of seeking out other attorneys who may be interested in doing this with me. No amount of money will ever replace those of us who, like me and many others, lost our dogs needlessly and painfully just to make vets more money and Lilly's shareholders and top brass even richer. However, class-action suits make companies wake up and pay attention, so this may be a very effective way to get the word out there that TRIFEXIS KILLS DOGS. Please let me know who may be interested. As I posted previously, there IS strength and power in numbers, even against a leviathan like Eli Lilly.

https://www.facebook.com/freakles2/posts/933015516714785
Her FB page: https://www.facebook.com/phoenix.foxx.5


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
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Re: Trifexis Adverse Events [Re: MaxaLisa] #327244
12/14/14 09:16 PM
12/14/14 09:16 PM
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Northern CA
MaxaLisa Offline

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Trifexis article, part 1 of 3
http://www.indystar.com/story/news/inves...cines/20247443/

This looks like it's going to be a really good series.


MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
Re: Trifexis Adverse Events [Re: MaxaLisa] #327410
12/18/14 06:56 PM
12/18/14 06:56 PM
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Northern CA
MaxaLisa Offline

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Trifexis article, part 2 of 3: http://www.indystar.com/longform/news/in...-vets/20492301/

Just adding, that I think there is info in these articles that apply to the general safety of all the meds that we give our pets. I think they are worth the read, even if you aren't interested in the trifexis issue.

Last edited by MaxaLisa; 12/18/14 07:00 PM.

MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
Re: Trifexis Adverse Events [Re: MaxaLisa] #327482
12/21/14 05:18 PM
12/21/14 05:18 PM
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Posts: 19,670
Northern CA
MaxaLisa Offline

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MaxaL (aka LisaT)

Jazmine, mini-mix, 10/18/2011
Max-n-Indy
Max, 5/2001-2/2012, RIP my partner, my Regal Boy
Indy, 5/1997-10/2010, RIP my friend, my teacher

Health Index
K9 TBD info and Tick List Links
http://www.rabieschallengefund.org/
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