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Heartworm and Flea Info/Links #110509
12/02/10 09:39 AM
12/02/10 09:39 AM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Northern CA
Heartworm Treatment Guidelines
http://veterinarynews.dvm360.com/dvm/Vet...ategoryId=40534
http://www.capcvet.org/capc-recommendations/canine-heartworm/

The mdr1 genetic mutation and heartworm medications
http://wsgenetics.org/mdr1.htm
http://www.vetmed.wsu.edu/depts-vcpl/drugs.aspx (Note that not only is ivermectin (heartguard) on this list, but so are Selamectin (Revolution), milbemycin (Interceptor and Sentinel), and moxidectin (Proheart6).

Timing Heartworm Medicatons
Alternative sites, use at your own risk:
http://www.tibetanmastiff.net/Heartworm.html
http://www.acreaturecomfort.com/heartworminfo.htm
http://terriermandotcom.blogspot.com/2008/05/billion-dollar-heartworm-scam.html?m=1
Please note, that this timing in this first link is used at your own, and your pet's, risk, as well as the recommendations in the second link. The American Heartworm Society is now recommending year-round prevention, even in seasonal areas: http://www.heartwormsociety.org/pet-owner-resources/canine-heartworm.html

The SafeHeart dose of Interceptor
(at 1/5 the "regular" dose, Interceptor is effective against only heartworms)
http://www.fda.gov/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM054862 (note that Interceptor is no longer on the market, but many products containing mili-whatever, the active ingredient, are.)

Flea Product Information
http://healthypets.mercola.com/sites/hea...and-sprays.aspx

Last edited by MaxaLisa; 06/15/14 03:37 PM.
Re: Heartworm and Flea Info/Product Information [Re: MaxaLisa] #150495
04/21/11 05:31 AM
04/21/11 05:31 AM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Joined: Jan 2010
Posts: 19,670
Northern CA
A recent groundbreaking study of clinical, histological and immunological data of 22 cases of Pemphigus foliaceus, or PF, shows evidence that it can occur as an adverse drug reaction to the canine flea and tick preventive ProMeris.

http://www.veterinarypracticenews.com/ve...production.aspx

Last edited by MaxaLisa; 06/18/11 04:06 AM.
Suit alleges heartguard plus cover up #159278
06/01/11 05:00 PM
06/01/11 05:00 PM
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Posts: 1,256
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myamom Offline
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myamom  Offline
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Posts: 1,256
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http://www.consumeraffairs.com/news04/2011/05/suit-alleges-heartgard-plus-cover-up.html

Suit Alleges Heartgard Plus Cover-Up

Drugmaker knew product was losing effectiveness in battling heart worm, fired scientist charges

05/31/2011 | Truman Lewis | ConsumerAffairs.com

The maker of Heartgard Plus, a heartworm drug used by millions of dog owners, "extortionately fired" its head of "global head of pharmacovigilance" after she refused to destroy documents questioning the drug's effectiveness, the Ph.D. claims in federal court.

In her suit against Merial LLC, the animal drug division of Sanofi Aventis, Dr. Kari Blaho-Owens says that she was hired in 2006 after the Food and Drug Administration (FDA) expressed concern about reports of Heartgard Plus being ineffective in preventing heartworm in dogs.

Blaho-Owens said that after reviewing the situation, she became aware that Merial had known of the problem since at least 2002 but had done nothing to update its labeling to specify that Hartgard Plus was not 100 percent effective in preventing heartworm.

Blaho-Owens said that in one discussion, Dr. Felipe Dolz, at this time Director of Regulatory Affairs, U.S., said that a labeling change would put Merial at a marketing disadvantage compared to competitors' products and that the company would prefer that FDA make the labeling change "product wide," meaning that it would also apply to competitors' drugs.

The suit alleges that internal studies conducted by the company were unscientific and used "cherry-picked" data to support the company's contention that the product was safe was used as indicated.

Non-compliance
In 2005, the FDA instructed Merial to change its labeling and to stop claiming 100 percent effectiveness and, the suit says, the company agreed to do so but didn't. In August 2006, the FDA warned Merial that it was in non-compliance.

In June 2007, seven months after Blaho-Owens began working at Merial, the FDA again issued a warning letter stating that the company had misbranded Heartgard Plus – this time because of its claim that the drug would prevent the spread of animal diseases to humans, even though Blaho-Owens said the company had no information to support that claim.

Blaho-Owens said that, instead, the company had evidence that heartworms had developed resistance to the active ingredients in Hartgard Plus and the company was actively working to reformulate it.

When Blaho-Owens questioned the company's practices, she was fired, the suit contends.

The suit charges Merial with violating the Whistleblower provision of the Sarbanes-Oxley Act.

Re: Suit alleges heartguard plus cover up [Re: myamom] #160386
06/08/11 05:10 PM
06/08/11 05:10 PM
Joined: Nov 2010
Posts: 29
GranvilleGSD Offline
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GranvilleGSD  Offline
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Joined: Nov 2010
Posts: 29
There is a new strain of Heartworm that has been discovered in the southern states. While some veterinary practices still recommend giving preventative only 9 months out of the year, it's now recommended to be on preventative year round, as this new strain takes 3 doses to kill, rather than 1. The preventative works by killing any heartworms they were exposed to in the month prior. So it actually deworms your dog for heartworm every month, it doesn't repel mosquitoes or heartworms or anything.

Re: Info on Flea, Tick, Mosquito, etc. Products [Re: GranvilleGSD] #174476
08/20/11 11:28 PM
08/20/11 11:28 PM
Joined: Jan 2010
Posts: 19,670
Northern CA
MaxaLisa Offline OP

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MaxaLisa  Offline OP

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Joined: Jan 2010
Posts: 19,670
Northern CA
Information on Flea, Tick, Mosquito, etc. Products can be found in this sticky:

http://www.germanshepherdhome.net/forum/ubbthreads.php/topics/63125.html#Post63125

Last edited by MaxaLisa; 08/26/11 02:13 AM.
Efficacy of HW preventive drugs #292689
08/22/13 11:14 AM
08/22/13 11:14 AM
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Posts: 2,032
MA
shepnterrier Offline
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shepnterrier  Offline
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Joined: Feb 2010
Posts: 2,032
MA
http://dogaware.com/articles/newshwresistance0711.html

A comprehensive article reviewing recent literature on the efficacy and side effects of different HW preventive drugs, especially with respect to HW strains that have developed drug resistance.

Does not cover drug failure due to manufacturing problems when the drug is not stable enough to last until expiration date and/or insufficient amounts of the drug in the medication (Iverhart by Virbac)


Sarah
Chip vom Dog Pound, border terrior, Director of Rodent Control, CGC
Elly von Rescue, GSD, CGC, HI(C)
Captain Jack, Mama Blue, Little Orca, Bübchen, Tux, Cherub (pocket lions)

Re: Efficacy of HW preventive drugs [Re: shepnterrier] #292693
08/22/13 01:07 PM
08/22/13 01:07 PM
Joined: Feb 2010
Posts: 2,032
MA
shepnterrier Offline
Pooh-Bah
shepnterrier  Offline
Pooh-Bah

Joined: Feb 2010
Posts: 2,032
MA


Sarah
Chip vom Dog Pound, border terrior, Director of Rodent Control, CGC
Elly von Rescue, GSD, CGC, HI(C)
Captain Jack, Mama Blue, Little Orca, Bübchen, Tux, Cherub (pocket lions)

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